A peptide nasal spray is an easy and safe way to deliver a therapeutic peptide directly into the brain. Peptide nasal sprays are often used to treat chronic pain and inflammatory conditions such as rheumatoid arthritis, but they can also be used for other symptoms such as depression and anxiety. Additionally, a peptide nasal spray can be used to promote muscle repair and improve recovery after surgery or injury. A reputable physician will use an established compounding pharmacy to prepare and deliver the peptide.
While peptides can be injected, they are more commonly administered through nasal administration because they are more effective and convenient. Moreover, the nasal mucosa is much more susceptible to the effects of peptides than the skin.
There are several ways to deliver peptides into the brain, including intravenous injection, intramuscular administration, and nasal inhalation. However, nasal administration is the most common method for delivery to the brain because it allows for rapid delivery, and results are visible in a short period of time.
Studies on the intranasal administration of peptides to the brain have revealed promising outcomes. For example, a study using the calcitonin gene-related peptide (CGRP) receptor antagonist ZAVZPRET showed that it effectively reduced migraine headaches in patients with migraine with aura. In addition, a similar study utilizing the peptide BP 157 reduced inflammation and promoted the growth of beneficial bacteria in the gut.
BP 157 is also known to support gastrointestinal health, and some studies suggest that it may reduce the risk of digestive disorders such as Crohn’s disease and IBS. The peptide also has anti-inflammatory effects, which makes it an excellent choice for reducing the pain associated with inflammatory conditions such as rheumatoid and lupus arthritis.
Another potential peptide nasal spray therapy is Orexin A, which is known to regulate sleep and wake cycles. Orexin A is a neuropeptide that has been shown to reduce sleep latency in mice and to increase wakefulness in humans. This peptide has also been shown to be a treatment for narcolepsy, as it reduces the frequency and duration of cataplexies in narcolepsy patients.
A recent clinical trial has demonstrated that Orexin A can be delivered via a nasal spray to the brain and reaches its intended target within minutes. This is the first evidence that a peptide can reach the brain via this direct route, and it validates earlier animal data. The peptide reached the brain through pathways that include nerves connecting the nasal cavity to the spinal cord and brain, and aqueous and lymphatic channels. The peptide’s lipophilic and ionic properties also likely contributed to the speed with which it reached its target. peptide nasal sprays